Biologists from RF are close to solve the riddle of the Alzheimer’s disease
In magazines Biophysical Journal and Journal of Biological Chemistry there was an article published about Russian scientists and their foreign colleagues who moved to a new level in studying of Alzheimer’s and Parkinson’s diseases. They managed to make deep research of three-dimensional structure of albumen.
Konstantin Mineev from the Institute of Biochemistry RAS in Moscow and his colleagues have studied receptors, with their help particles are being read by neurons. The albumen p75 is one of the most important receptors of such type.
If p75 works not in normal regime neurons in the midbrain begin to die out that results progress of Alzheimer’s and Parkinson’s diseases. In normal regime p75 is managing the growth of nerve endings and neurons migration. For p75 research the scientists had to use NMR-spectroscope and special “nanodisc” because receptor is situated in membrane and consists from several parts which interact together.
More than that scientists found out that if there are some anomalies and mutations happen in the albumen the work of p75 also suffers. Researchers also supposed that the inner and exterior parts of p75 were “boiling down” and “stretching” independently of each other.
It is noted that researches of such type should help to scientists from all over the world to find a method of medicine creation to help in fight against different diseases. Sure now this sphere needs lots of reworks.